Publications Klaus Schümann

 

Original papers since 1999

 

Schümann K, Elsenhans B, Forth W (1999) Kinetic analysis of ⁵⁹Fe movement across the intestinal wall in iron-deficient and iron-adequate duodenal rat segments ex vivo. Am J Physiol 276: G431-G440

Elsenhans B, Hunder G, Strugala G, Schümann K (1999) Longitudinal pattern of enzymatic and absorptive functions in the small intestine of rats after short-term exposure to dietary cadmium chloride. Arch Environ Contam Toxicol 36: 341-346

Schümann K, Moret R, Künzle H, Kühn LC (1999) Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption. Eur J Biochem 260: 362-372

Bahram S, Gilfillan S, Kühn LC, Moret R, Schulze JB, Lebeau A, Schümann K (1999) Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism. PNAS 96: 13312-13317

Hunder G, Javdani J, Elsenhans B, Schümann K (2000) Use of γ -spectrometry for simultaneous determination of ²¹⁰Pb, ⁷³As, ¹⁰⁹Cd, ²⁰³Hg and ⁵⁹Fe distribution and excretion in rats at low doses. Toxicology 150: 69-82

Hunder G, Javdani J, Elsenhans B, Schümann K (2001) ¹⁰⁹Cd accumulation in the calcified parts of rat bones. Toxicology 159: 1-10

Lebeau A, Frank J, Biesalski HK, Weiss G, Srai SKS, Simpson RJ, McKie A, Bahram S, Gilfillan S, Schümann K (2002) Long-term biochemical and pathomorphological sequels of HFE deletion in C57BL/6 mice, an animal model for human hereditary hemochromatosis. Eur J Clin Invest 32: 603-612

Flaig K-H, Schümann K, Elsenhans B (2003) Jejunal transfer rates of ¹⁰⁹cadmium chloride increase in rats in vitro and in vivo after oral pretreatment with cadmium or zinc chloride. Toxicology 183: 199-209

Scharl M, Elsenhans B, McKie A, Schümann K (2003) Adaptation of Ni²⁺ absorption to iron deficiency in rat jejunal segments ex vivo. Toxicology 185: 141-153

Simpson RJ, Debnam ES, Laftah AH, Beaumont N, Bahram S, Schümann K, Srai SKS (2003) Duodenal non-heme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out. Blood 101: 3316-3318

Simpson RJ, Depnam E, Beaumont N, Bahram S, Schümann K, Srai SKS (2003) Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding. Gut 52: 510-513

Laftah AH, Simpson, Beaumont N, Bahram S, Schümann K, Srai SKS (2003) Hypoxic response of iron absorption is not affected by the HFE gene knock-out mice. Br J Haematol 123: 170-172

K. Schümann, K. Brennan, Weiss, K. Pantopoulos, Hentze MW (2004) Rat duodenal IRP1 activity and iron absorption in iron deficiency and after H₂O₂ perfusion. Eur J Clin Invest 34: 275-282

Laftah H, Ramesh B, Simpson RJ, Solanky N, Bahram S, Schümann K, Debnam ES, Srai SKS (2004) Effect of hepcidin on intestinal iron absorption in mice. Blood 103: 3940-3944

Dhonukshe-Rutten RAM, Vossenaar M, West CE, Schümann K, Bulux J, Solomons NW (2005) Day-to-day variation in iron, zinc and copper in breast milk of Guatemalan mothers. J Pediatr Gastroenterol Nutr 40: 128-134

Magens B, Düllmann J, Schümann K, Wulfhekel U, Nielsen P (2005) Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunochemical analysis. Acta Histochem 107: 57-65

Schümann K, Kroll S, Weiss G, Frank J, Biesalski HK, Daniel H, Friel J, Solomons NW (2005) Monitoring of haematological, inflammatory and oxidative reactions to acute oral iron exposure in human volunteers: preliminary screening for selection of potentially-responsive biomarkers. Toxicology 212: 10-23

Schümann K, Romero-Abal M-E, Mäurer A, Luck T, Beard J, Murray-Kolb L, Bulux J, Mena I, Solomons NW (2005) Impact of 10 weeks intervention with heme- and FeSO₄-fortified beans as supplementary diet on hemoglobin concentration in Guatemalan infants. Publ Health Nutr 8: 572-581

Ludwiczek S, Theurl I, Bahram S, Schümann K, Weiss G (2005) Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. J Cell Physiol 204: 489-499

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW (2005) Altered body iron distribution and microcytosis in mice deficient of Iron-Regulatory Protein 2 (IRP2). Blood 106: 2580-2589

Schümann K, Lebeau A, Ettle T, Adam O (2005) Adjuvant challenge in rats may lead to dermatitis instead of arthritis. Rheumatol Internat 26: 393-395

Ettle T, Elsenhans B, Windisch W, Srai SKS, Schümann K (2006) Mobilisation of recently absorbed ⁵⁹Fe in ex vivo perfused rat duodena and the influence of iron status and subsequently absorbed chelators. J Trace Elem Med Biol 19: 231 – 241

Schümann K, Szegner B, Kohler B, Pfaffl M, Ettle T (2007) A method to assess ⁵⁹Fe in residual tissue blood content in mice and its use to correct ⁵⁹Fe-ditribution kinetics accordingly. Toxicology 241: 19-32

Szegner B, Herbach N, Ettle T, Elsenhans B (2007) Assessing and influencing the fractional contribution of erythrocyte-bound ⁵⁹Fe to individual ⁵⁹Fe tissue content in murine ⁵⁹Fe distribution studies. Toxicology 244: 198-208

Theurl M, Theurl I, Hochegger K, Obrist P, Subramaniam N, van Rooijen N, Schümann K, Weiss G (2008) Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression. J Mol Med 86: 225-235

Longfils P, Monchy D, Weinheimer H, Chavasit V, Nakanishi Y, Schümann K (2008) An intervention trial of iron fortified fish sauce in iron-deficiency anemia (IDA) school children aged 6 to 21 years of age in Kampot, Cambodia. Asian Pacific J Clin Nutr 17: 250-257

Schümann K, Longfils P, Monchy D, Xylander S, Weinheimer H, Solomons NW (2009) A placebo-controlled intervention trail of iron supplementation with and without multi-micronutrients in anaemic children aged 6 to 24 months in Kampot, Cambodia. Eur J Clin Nutr 63:355-368

Werner T, Hoermannsperger G, Schuemann K, Hoelzlwimmer G, Tsuji S, Haller D (2009) Intestinal epithelial cell proteome from wild-type and TNF^ΔARE/WT mice: effect of iron on the development of chronic ileitis. J Proteome Res 8: 3252-3264

Schümann K, Herbach N, Kerling C, Seifert M, Fillebeen C, Prysch I, Reich J, Weiss G, Pantopoulos K (2010) Iron absorption and distribution in TNF^ΔARE/+ mice, a model of chronic inflammation. J Trace Elements Med Biol 24:58-66

Orozco M, Solomons NW, Schümann K, Friel JK, Mendizabal de Montenegro AL (2010) Antioxidant-rich Oral Supplements Attenuate the Effects of Oral Iron on In Situ Oxidation Susceptibility of Human Feces. J Nutr 149:1105-1110

Lopes TJ, Luganskaja T, Vujic-Spasic M, Hentze MW, Muckenthaler MU, Schümann K, Reich JG (2010) Systems Analysis of Iron Metabolism: The Network of Iron Pools and Fluxes. BMC Syst Biol 4:112 (http://www.biomedcentral.com/content/pdf/1752-0509-4-112.pdf)

Solomons NW, Romero-Abal ME, Weiss G, Michalke B, Schümann K (2011) Bioavailability of zinc from Nutriset zinc tablets compared to aqueous zinc sulphate. Eur J Clin Nutr 65: 125-131

Crowley CR, Montenegro-Bethancourt G, Arriaga C, Solomons NW, Schümann K (2010) Correspondence of a non-invasive, cutaneous-contact method to determine hemoglobin values with conventional whole blood samples within a Guatemalan field setting. Food Nutr Bull 31:503-512

Vanoaica L, Darshan D, Richman L, Schümann K, Kühn LC (2010) Intestinal ferritin H is required for an accurate control of iron absorption. Cell Metabol 12:273-282

Werner T, Wagner SJ, Martinez I, Walter J, Chang JS, Clavel T, Kisling S, Schümann K, Haller D (2011) Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis. Gut 60: 325-333

Schümann K, Solomons NW, Laarakkers CM, Romero-Abal M-E, Kroll S, Weiss G, Swinkels DW (2010) Reproducibility and correspondence among different hepcidin forms in blood and urine and their relationships to iron status in healthy, male Guatemalan volunteers observed over 9 weeks. Ann Nutr Metabol, in press

Elsenhans B, Janser H, Windisch W, Schümann K (2011) Does lead use the intestinal absorptive pathways of iron? Impact of iron status on murine ²¹⁰Pb and ⁵⁹Fe absorption in duodenum and ileum in vivo Toxicology 284: 7-11

Orozco M, Solomons NW, Schümann K, Friel JK (2010) The response of urinary biomarkers of systemic oxidation, thiobarbituric acid reactive substances (TBARS) and 8-hydroxy-2-deoxy-guanosine (8-OHdG), to oral iron supplementation in healthy men, with notes on the putative biological significance of their day-to-day fluctuation within the non-pathological range. Br J Nutr, submitted

Lietz G, Montenegro-Bethancourt G, Sud S, Schümann K, Solomons NW (2010) Frequency of the common R267S and A379V polymorphism within the β-carotene 15,15'-monooxigenase gene in a Mayan population. Am J Clin Nutr, submitted

Schümann K, Solomons NW, Romero-Abal M-E, Orozco M, Weiss G, Marx JJM (2010) Oral administration of ferrous sulfate, but not of iron polymaltose and sodium iron EDTA, results in a substantial increase of non-transferrin-bound iron in healthy men. Ann Nutr Metabol, submitted

Schümann K, Kroll S, Romero-Abal M-E, Marx JJM, Weiss G, Solomons NW (2010) Impact of iron status and oral iron challenges on circulating non-transferrin-bound iron (NTBI) in healthy Guatemalan males. Ann Nutr. Metabol, submitted

Crowley C, Montenegro-Bethancourt G, Solomons NW, Schümann K (2010) Validity and correspondence of non-invasively determined hemoglobin concentrations by two trans-cutaneous digital measuring devices. APJCN, submitted

Theil EC, Chen H, Miranda C, Janser H, Walter T, Elsenhans B, Nunez MT, Pizarro F, Schűmann K (2011) The intestine absorbs iron differently from ferritin and small iron complexes. J Nutr, submitted

 

 

Reviews, comments, letters to the editor, textbook contributions since 1999

 

Schümann K (1999) Interactions between drugs and vitamins at advanced age. Int J Vitam Nutr Res 69: 173-178

Schümann K, Pharmakotherapie des Diabetes mellitus (1999); PHA 7-11

Schümann K, Pharmakotherapie in der Gastroenterologie (1999); PHA 17-22

Schümann K, Pharmakotherapie in der Geriatrie (1999); PHA 23-26

Schümann K, Röntgenkontrastmittel (1999); PHA 77-81

In: Kompaktwissen Innere Medizin, Zimmermann W, Koch K, Amarotico A (eds)
Dustri-Verlag, Deisenhofen (1999)

Schümann K, Hunder G (1999) Der Eisenmangel bei Kindern, Teil I. Kinder- u. Jugendarzt 30: 812-815

Schümann K, Hunder G (1999) Der Eisenmangel bei Kindern, Teil II. Kinder- u. Jugendarzt 30: 908-911

Schümann K, Classen HG, Dieter HH, König J, Multhaup G, Rückgauer M, Summer KH, Bernhardt J, Biesalski HK (1999) Hohenheimer Konsensusgespräch Kupfer. Akt Ernähr Med 24: 283-296

Schümann K, Elsenhans B, Richter E (1999) Gastrointestinal Tract. In: Toxicology, Marquardt H, Schäfer S, McClellan R, Welsch F, eds, Academic Press, San Diego, Ch. 23, pp 573-585

Schäfer SG, Dawes R, Elsenhans B, Forth W, Schümann K (1999) Metals. In: Toxicology, Marquardt H, Schäfer S, McClellan R, Welsch F, eds, Academic Press, San Diego, Ch. 32, pp 755-804

Mäurer A, Schümann K (2000) Abbatoir blood used in foods: an example of nutrition-environment interaction. UN System´s Forum on Nutrition 21: 32-33

Schümann K (2001) Safety aspects of iron in food. Ann Nutr Metabol 45: 91-101

Schümann K (2001) Eisen in der Nahrung. Ernährungs-Umschau 48: 199-200

Schümann K, Classen HG, Dieter HH, König J, Multhaup G, Rükgauer M, Summer KH, Bernhardt J, Biesalski HK (2002) Hohenheimer Consensus Workshop: Copper. Eur J Clin Nutr 56: 469-483

Schümann K, Elsenhans B (2002) The impact of contaminants on the bioavailability of trace metals. J Trace Elements Med Biol 16: 139-144

Biesalski HK, Köhrle J, Schümann K, eds: Vitamine, Spurenelemente, Mineralstoffe, Thieme-Verlag, Stuttgart, (2002), 812 pages

Schümann K, Weiss G. Eisen. pp 137-147

Schümann K., Kupfer. pp 147-151

Schümann K., Hunder G., Adam O. Gold. pp 242-244

Schümann K., Hunder G., Adam O. Lithium. pp 244-246

Schümann K., Hunder G., Adam O. Bismuth. pp 246-247

Brätter P, Heseker H, Liesen H, Kruse-Jarres JD, Negretti de Brätter V, Pietrzik K, Schümann K, eds: Mineralstoffe, Spurenelemente und Vitamine, Verlag Bertelsmann Stiftung, Gütersloh 2002

Solomons NW, Schümann K (2002) Collateral damage in the battle against hypovitaminosis A? Am J Clin Nutr 75: 659-661

Solomons NW, Schümann K (2002) Lessons learned in iron intervention trials. Am J Clin Nutr 76: 691-693

Schümann K, Borch-Iohnsen B, Hentze MW, Marx JM (2002) Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board. Am J Clin Nutr 76: 499-500

Finley D, Schumann K, Hess-Bienz D (2002) Monitoring and impact evaluation of a multi-micronutrient supplementation program. Food Nutr Bull 23: 312-313

Schümann K. Bedeutung und Grenzen der Eisenhomöostase. In: Praxishandbuch Functional Food, Erbersdobler HF, Meyer AH, eds, B Behrs Verlag, Hamburg, 8. Ergänzung (2002), Ch. 4.4, pp 1-16

Schümann K (2003) Toxicological aspects of iron. In: Modern aspects of nutrition, present knowledge and future perspectives. Elmadfa I, Anklam E, König JS, eds, Karger Forum of Nutrition 56, 51-53

Schümann K, Mäurer A, Elsenhans B, Solomons NW. Überlegungen und Befunde zur Eisenfortifikation von Nahrungsmitteln in der 3. Welt. In: Signalwirkungen von Mineralstoffen und Spurenelementen, Rükgauer M, ed, Wissenschaftliche Verlagsgesellschaft, Stuttgart (2003), pp 67-70

Schäfer SG, Elsenhans B, Forth W, Schümann K. Metalle. In: Lehrbuch der Toxikologie, Marquardt H, Schäfer S, eds, Wissenschaftliche Verlagsgesellschaft, Stuttgart, (2004), 2.Auflage, Ch. 31, pp 763-820

Solomons NW, Schümann K (2004) Editorial: Intramuscular iron dextrane is not appropriate for moderate anemia of pregnancy: not in intervention research on underprivileged women, and never in routine public health care. Am J Clin Nutr 79: 1-3

Schümann K, Elsenhans B. Iron. In: Merian E, Anke M, Ihnar M, Stoeppler M, eds, Elements and their Compounds in the Environment, sec. ed., Wiley-VCH, Weinheim (2004), 2. Auflage, Bd. 3, Ch 13.1, pp 811-824

Schümann K, Anke M. Mengenelemente. In: Ernährungsmedizin, Biesalski KH, Fürst P, Kasper H, Kluthe R, Pölert W, Puchstein C, Stähelin HB; eds, 3. Aufl., Thieme Verlag, Stuttgart, (2004), pp. 167-172

Anke M, Schümann K. Spurenelemente. In: Ernährungsmedizin, Biesalski KH, Fürst P, Kasper H, Kluthe R, Pölert W, Puchstein C, Stähelin HB; eds, 3. Aufl., Thieme Verlag, Stuttgart, (2004), pp. 173 – 186

Solomons NW, Schümann K (2004) Update on vitamin A-related deaths in Assam. Reply to letter by Dr. Kapil (Letter to the Editor). Am J Clin Nutr 80: 1083-1084

Schümann K (2006) Dietary reference intakes for trace elements revisited. J Trace Elem Med Biol 20: 59-61

Schümann K, Ettle T, Szegner B, Elsenhans B, Solomons NW (2007) On risks and benefits of iron supplementation recommendations for iron intake revisited. J Trace Elem Med Biol 21: 147-168

Schümann K, Solomons NW. Safety of interventions to reduce nutritional anemias. In: Nutritional Anemia, Kraemer K, Zimmermann MB, eds, Sight and Life Press, Ch 18, Basel 2007, pp 285 – 314

Schümann K, Christ F (2007) Did the "iron age" end in Pemba? Sight and Life Magazine 3/2007: 6-13

Ettle T, Elsenhans B, Schümann K. Eisen. In: Dunkelberg H, Hartwig A, Gebel T, eds, Handbuch der Lebensmitteltoxikologie, Wiley-VCH-Verlag, Weinheim, 2007, Ch 55, pp 2265-2315

Schümann K, Köhrle J. Molecular mechanisms of iodine-related disease states. In: Lang F, ed, Molecular Mechanisms of Diseases – An Encyclopedic Reference, Springer Verlag, 2007

Schümann K, Weiss G. Hereditary hemochromatosis. In: Lang F, ed, Molecular Mechanisms of Diseases – An Encyclopedic Reference, Springer Verlag, 2007

Schümann K, Weiss G. Acute iron intoxication. In: Lang F, ed, Molecular Mechanisms of Diseases – An Encyclopedic Reference, Springer Verlag, 2007

Schümann K, Weiss G. Iron deficiency. In: Lang F, ed, Molecular Mechanisms of Diseases – An Encyclopedic Reference, Springer Verlag, 2007

Schümann K, Solomons NW (2010) Efficacy and safety of iron administration in juvenile populations. Ann Nestle 68:132-140

Solomons NW, Orozco M, Crowley C, Romero-Abal ME, Schümann K (2010) Iron: Nutrition’s two-edged sword. Sight and Life Magazine 2/2010:20-24