Interaction between Inflammation and Adiposity

Determination of bioelectric impedance

The foundation supports research on the interaction between adiposity, inflammation and the mechanisms of iron metabolism.

Background

Adiposity should go along with chronic inflammation which, in turn, should influence iron metabolism and lead to anemia of inflammation. Due to the increasing prevalence of adiposity worldwide, along with increasing insight into the negative consequences of this pandemia e.g. for the prevalence of diabetes and cardiovascular diseases this type of interaction attracts increasing attention. Even in poor countries like Guatemala the prevalence of adiposity is meanwhile overtaking that of nutritional deficiencies. For orientation the foundation had three reviews written on the interaction between the pathomechanisms that work in adiposity, in inflammation, and in iron-homoeostasis. In addition, a study was performed in two murine models of inflammation (ref). In order to assess the extent and location of excessive body fat in Guatemala we used body impedance analysis (= BIA). This method builds on the observation that electric impedance differs between different types of tissue, depending, among others, on its content electrolytes. Thus, for example it is higher in fat than in muscle tissue. To determine such differences permits to assess the per cent contribution of fat to total body tissue in different parts of the body and its location (SECA – add details of the device). The foundation purchased two such devices and had its staff trained in its use.

The goal of our related projects is to assess frequency of occurrence, extent and location of excessive fat in the body in different regions of Guatemala. A second approach may later try toe assess the relationship between the extent of adiposity and its impact on indicators of inflammation as well as on iron metabolism. If results are favorable one may think of assessing the impact of weight reduction on this relationship. A second project will aim at the assessment of body hydration status which can be used to investigate to what extent fluid intake is adequate in different segments of Guatemala’s population or to control the hydration status in patients on Hemodialysis.

Corresponding publications

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R25: Iron metabolism in obesity: How interaction between homoeostatic mechanisms can interfere with their original purpose. Part I: Underlying homoeostatic mechanisms of energy storage and iron metabolisms and their interaction R26: Iron metabolism in obesity: How interaction between homoeostatic mechanisms can interfere with their original purpose. Part II: Epidemiological and historic aspects of the iron/obesity interaction I52: The growth attainment, hematological, iron status and inflammatory profile of Guatemalan juvenile end-stage renal disease patients