Iron: Nutritional Deficiency and Excess (Chapter 3.2)

Sustainability. In: Lexicon for an Anthropocene Yet Unseen.

The Social Life of Metrics. Histórias of Zika, of the Somatosphere series

Head circumference. Histórias of Zika, of the Somatosphere series

Vision of Research on Human Linear Growth

A Vision for Nutritional Research for the Latin American Region

Towards appropriate feeding to prevent malnutrition in infants and toddlers

Dietary vitamin A intake recommendations revisited: global confusion requires alignment of the units of conversion and expression

What Makes It So Difficult to Mitigate Worldwide Anemia Prevalence?

Normative Fecal Calprotectin Concentrations in Guatemalan Preschoolers Are High Relative to Children Reported Elsewhere

Interaction of Giardia intestinalis and Systemic Oxidation in Preschool Children in the Western Highlands of Guatemala

Correction: Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands

Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands

The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients

Variation in hydration status within the normative range is associated with urinary biomarkers of systemic oxidative stress in Guatemalan preschool children

Associations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemala

Iron metabolism in obesity: How interaction between homoeostatic mechanisms can interfere with their original purpose. Part II: Epidemiological and historic aspects of the iron/obesity interaction

Iron metabolism in obesity: How interaction between homoeostatic mechanisms can interfere with their original purpose. Part I: Underlying homoeostatic mechanisms of energy storage and iron metabolisms and their interaction

Risiken und Nutzen der Eisensupplementation: Empfehlungen zur Eisenaufnahme kritisch betrachtet

Can iron supplementation be reconciled with benefits and risks in areas hyperendemic for malaria?

A man for all seasons. A tribute to Manfred Anke

Eisen

Iron: Nutrition’s two-edged sword

Efficacy and safety of iron administration in juvenile populations

Rainer Gross’ legacy

Iron deficiency

Acute iron intoxication

Hereditary hemochromatosis

Iodine-related disease states

Versuche zur Erfassung der ⁵⁹Fe-Aktivität in den Erythrozyten bei ⁵⁹Fe-Verteilungsstudien in Mäusen

Positive und negative Auswirkungen der Gabe von Eisensupplementen auf die Gesundheit von Kleinkindern in Malaria-endemischen Gebieten

Eisen

On risk and benefits of iron supplementation recommendations for iron intake revisited

Did the “iron age” end in Pemba?

Safety of interventions to reduce nutritional anemias

Update on vitamin A-related deaths in Assam. Reply to letter by Dr. Kapil (Letter to the Editor)

Editorial: Intramuscular iron dextrane is not appropriate for moderate anemia of pregnancy: not in intervention research on underprivileged women, and never in routine public health care

Überlegungen und Befunde zur Eisenfortifikation von Nahrungsmitteln in der 3. Welt

Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board

Lessons learned in iron intervention trials

Collateral damage in the battle against hypovitaminosis A?

Abbatoir blood used in foods: an example of nutrition-environment interaction

Human Milk Microbiota in an Indigenous Population Is Associated with Maternal Factors, Stage of Lactation, and Breastfeeding Practices

Distinct Changes Occur in the Human Breast Milk Microbiome Between Early and Established Lactation in Breastfeeding Guatemalan Mothers

Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial

Anthropometry before Day 46 and Growth Velocity before 6 Months of Guatemalan Breastfed Infants Are Associated with Subclinical Mastitis and Milk Cytokines, Minerals, and Trace Elements

Endocannabinoid Metabolome Characterization of Milk from Guatemalan Women Living in the Western Highlands

Infant growth faltering linked to subclinical mastitis, maternal faecal–oral contamination, and breastfeeding

Nutrient Density as a Dimension of Dietary Quality. Part II: Harmonization of the investigational protocol in a multicenter evaluation

Nutrient Density as a Dimension of Dietary Quality. Part I: Theoretical considerations of the nutrient-density approach in a multicenter evaluation

Several problem nutrients are identified in the complementary diet of 6 to 11 month old breastfed children in Western Guatemala

Subclinical mastitis (SCM) and proinflammatory cytokines are associated with mineral and trace element concentrations in human breast milk

Upregulation of Zinc Absorption Matches Increases in Physiologic Requirements for Zinc in Women Consuming High- or Moderate-Phytate Diets during Late Pregnancy and Early Lactation

Vitamin D status among indigenous Mayan (Kekchi) and Afro-Caribe (Garifuna) adolescents from Guatemala: a comparative description between two ethnic groups residing on the Rio Dulce at the Caribbean coast in Izabal Province, Guatemala

Normative Fecal Calprotectin Concentrations in Guatemalan Preschoolers are High Relative to Children Reported Elsewhere

The potential double-burden of vitamin A malnutrition: under- and overconsumption of fortified table Sugar in the Guatemalan highlands

Interaction of Giardia intestinalis and Systemic Oxidation in Preschool Children in the Western Highlands of Guatemala

Effects of maternal hydration status on the osmolality of maternal milk

Minerals and Trace Elements in Human Breast Milk Are Associated with Guatemalan Infant Anthropometric Outcomes within the First 6 Months

Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands

The stunted child with an overweight mother as a growing public health concern in resource-poor environments: a case study from Guatemala

Effects of maternal hydration status on the osmolality of maternal milk

Minerals and Trace Elements in Human Breast Milk Are Associated with Guatemalan Infant Anthropometric Outcomes within the First 6 Mo

Normative fecal calprotectin concentrations in Guatemalan preschoolers are high relative to children reported elsewhere

The potential double-burden of vitamin A malnutrition: under- and overconsumption of fortified table sugar in the Guatemalan highlands

Vitamin D status among indigenous Mayan (Kekchi) and Afro-Caribe (Garifuna) adolescents from Guatemala: a comparative description between two ethnic groups residing on the Rio Dulce at the Caribbean coast in Izabal Province, Guatemala

Interrelationship between maternal subclinical mastitis (SCM) and infant anthropometry in Guatemala: Role of infection, inflammation, hygiene and lactation practices

The stunted child with an overweight mother as a growing public health concern in resource-poor environments: A case study from Guatemala

Interaction of Giardia intestinalis and Systemic Oxidation in Preschool Children in the Western Highlands of Guatemala

Strong associations exist among oxidative stress and antioxidant biomarkers in the circulating, cellular and urinary compartments in Guatemalan children from the Western Highlands

Energy contribution from non-breastmilk items in low-income Guatemalan infants in their sixth month of life

Associations among inflammatory biomarkers in the circulating, plasmatic, salivary and intraluminal compartments in apparently healthy preschool children, from the Western Highlands of Guatemala

Variation in hydration status within normative range is associated with urinary biomarkers of sytemic oxidative stress in Guatemalan preschool children

Stunting at birth: recognition of early-life linear growth failure in the western highlands of Guatemala

The Nutritional Contribution of Foods and Beverages Provided by Government-Sponsored Day Care Centers in Guatemala

Feeding patterns before 6 months of age: the relative validity of recall from interviews of mothers of Guatemalan infants and toddlers

Urinary osmolality of preschool children with a largely common weekday meal offering, from the western highlands of Guatemala

Long-term Urine Biobanking: Storage stability of clinical chemical parameters under moderate freezing conditions without use of preservatives

Earlier introduction of aguitas is associated with higher risk of stunting in infants and toddlers in the Western Highlands of Guatemala

Highland Guatemalan women are extremely short of stature, and no lactation duration effects on body composition are observed in a cross-sectional survey

Nutrient density in complementary feeding of infants and toddlers

Stunting rates in infants and toddlers born in metropolitan Quetzaltenango, Guatemala

Contribution of fruit and vegetable intake to hydration status in schoolchildren

Estimates of exclusive breastfeeding rates among mother-infant dyads in Quetzaltenango, Guatemala, vary according to interview method and time frame

Daily consumption of foods and nutrients from institutional and home sources among young children attending two contrasting day-care centers in Guatemala City

The concept of “critical nutrient density” in complementary feeding: the demands of the “family foods” for the nutrient adequacy of young Guatemalan children with continued breastfeeding

Ritual fluids in relation to early child nutrition in Quetzaltenango, Guatemala

Evaluating food menus from day care centers in Guatemala City: Descriptive and analytical approaches for consideration in Nutrition

Beverage consumption and anthropometric outcomes among schoolchildren in Guatemala

Agreement between dietary and lifestyle guidelines for cancer prevention in population samples of Europeans and Mesoamericans

Bioavailability of zinc from NutriSet zinc tablets compared with aqueous zinc sulfate

Food variety, dietary diversity, and food characteristics among convenience samples of Guatemalan women

Contribution of complementary food nutrients to estimated total nutrient intakes for urban Guatemalan infants in the second semester of life

Reproducibility regarding the age of introduction of complementary foods to infants as self-reported by urban and rural low-income mothers in Guatemala

Nutrient offerings from the meals and snacks served in four day care centres in Guatemala City

Concordance with selected population recommendations for cancer prevention among third- and fourth-grade schoolchildren in Quetzaltenango, Guatemala

Practical limitations to a positive deviance approach for identifying dietary patterns compatible with the reduction of cancer risk

Concordance with dietary lifestyle population goals for cancer prevention in Dutch, Scottish, Mexican, and Guatemalan population samples

Contribution of complementary food nutrients to estimated total nutrient intakes for rural Guatemalan infants in the second semester of life

Contribution of complementary foods to the total daily water needs of urban Guatemalan infants

Dietary intakes and food sources of fat and fatty acids in Guatemalan schoolchildren: a cross-sectional study

Contribution of beverages to energy, macronutrient and micronutrient intake of third- and fourth-grade schoolchildren in Quetzaltenango, Guatemala

Volume, frequency and participation in plain drinking water consumption by third- and fourth-grade schoolchildren in Quetzaltenango, Guatemala

Total dietary water intake in Guatemalan Children

Ready-to-eat cereals are key sources of selected micronutrients among schoolchildren from public and private elementary schools in Quetzaltenango, Guatemala

Distribution of macro- and micronutrient intakes in relation to the meal pattern of third- and fourth-grade schoolchildren in the city of Quetzaltenango, Guatemala

Dietary characteristics of complementary food offered to Guatemalan infants vary between urban and rural settings

The positive deviance approach can be used to create culturally appropriate eating guides compatible with reduced cancer risk

Concordance with the New American Plate guidelines of the American Institute for Cancer Research in Guatemalan children

Evaluating concordance with the 1997 World Cancer Research Fund/ American Institute of Cancer Research cancer prevention guidelines: challenges for the research community

3.2 Iron: Nutritional Deficiency and Excess

Iron and Zinc: Two Principal Trace Element Nutrients in the Context of Food Security Transitions

Inflammation neither increases hepatic hepcidin nor affects intestinal ⁵⁹Fe-absorption in two murine models of bowel inflammation, hemizygous TNF^ΔARE/+ and homozygous IL-10^-/- mice

Iron-homeostasis and obesity

The growth attainment, hematological, iron status and inflammatory profile of Guatemalan juvenile end-stage renal disease patients

Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin: Genetic evidence from single and double knockout mice

Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation

⁵⁹Fe-distribution in conditional ferritin-H-deleted mice

Iron regulatory proteins control a mucosal block to intestinal iron absorption

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function

Differences in circulating non-transferrin-bound iron after oral administration of ferrous sulfate, sodium iron EDTA, or iron polymaltose in women with marginal iron stores

Targeted provision of oral iron: The evolution of a practical screening option

Validity and correspondence of non-invasively determined hemoglobin concentrations by two trans-cutaneous digital measuring devices

Equivalent effects on fecal reactive oxygen species generation with oral supplementation of three iron compounds: ferrous sulfate, sodium iron EDTA and iron polymaltose

Studies on variation in fecal reactive oxidative species generation in free-living populations in Guatemala

Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments

Oral administration of ferrous sulfate, but not of iron polymaltose or sodium iron ethylenediaminetetraacetic acid (NaFeEDTA), results in a substantial increase of non-transferrin-bound iron in healthy iron-adequate men

Response of urinary biomarkers of systemic oxidation to oral iron supplementation in healthy men

Impact of iron status and oral iron challenges on circulating non-transferrin-bound iron (NTBI) in healthy Guatemalan males

Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis

Does lead use the intestinal absorptive pathways of iron? Impact of iron status on murine ²¹⁰Pb and ⁵⁹Fe absorption in duodenum and ileum in vivo

Reproducibility and correspondence among different hepcidin forms in blood and urine and their relationships to iron status in healthy, male Guatemalan volunteers observed over 9 weeks

Bioavailability of zinc from Nutriset zinc tablets compared to aqueous zinc sulphate

Intestinal ferritin H is required for an accurate control of iron absorption

Correspondence of a non-invasive, cutaneous-contact method to determine hemoglobin values with conventional whole blood samples within a Guatemalan field setting

Systems Analysis of Iron Metabolism: The Network of Iron Pools and Fluxes

Antioxidant-rich Oral Supplements Attenuate the Effects of Oral Iron on In Situ Oxidation Susceptibility of Human Feces

Iron absorption and distribution in TNFΔARE/+ mice, a model of chronic inflammation

Intestinal epithelial cell proteome from wild-type and TNFΔARE/WT mice: effect of iron on the development of chronic ileitis

Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: a placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age

A comparative intervention trial on fish sauce fortified with NaFe-EDTA and FeSO₄⁺citrate in iron deficiency anemic school children in Kampot, Cambodia

Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression

Assessing and influencing the fractional contribution of erythrocyte-bound ⁵⁹Fe to individual ⁵⁹Fe tissue content in murine ⁵⁹Fe distribution studies

A method to assess ⁵⁹Fe in residual tissue blood content in mice and its use to correct ⁵⁹Fe-ditribution kinetics accordingly

Mobilisation of recently absorbed ⁵⁹Fe in ex vivo perfused rat duodena and the influence of iron status and subsequently absorbed chelators

HgCl₂ challenge in Brown Norway rats lead to dermatitis instead of arthritis

Altered body iron distribution and microcytosis in mice deficient of Iron-Regulatory Protein 2 (IRP2)

Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis

Haematological response to haem iron or ferrous sulphate mixed with refried black beans in moderately anaemic Guatemalan pre-school children

Monitoring of haematological, inflammatory and oxidative reactions to acute oral iron exposure in human volunteers: preliminary screening for selection of potentially-responsive biomarkers

Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunochemical analysis

Day-to-day variation in iron, zinc and copper in breast milk of Guatemalan mothers

Effect of hepcidin on intestinal iron absorption in mice

Rat duodenal IRP1 activity and iron absorption in iron deficiency and after H₂O₂ perfusion

Hypoxic response of iron absorption is not affected by the HFE gene knock-out mice

Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding

Duodenal non-heme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out

Different behaviour of ⁶³Ni and ⁵⁹Fe during absorption in iron-deficient and iron-adequate jejunal rat segments ex vivo

Jejunal transfer rates of ¹⁰⁹cadmium chloride increase in rats in vitro and in vivo after oral pretreatment with cadmium or zinc chloride

Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis

¹⁰⁹Cd accumulation in the calcified parts of rat bones

Use of γ -spectrometry for simultaneous determination of ²¹⁰Pb, ⁷³As, ¹⁰⁹Cd, ²⁰³Hg and ⁵⁹Fe distribution and excretion in rats at low doses

Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism

Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption

Longitudinal pattern of enzymatic and absorptive functions in the small intestine of rats after short-term exposure to dietary cadmium chloride

Kinetic analysis of ⁵⁹Fe movement across the intestinal wall in iron-deficient and iron-adequate duodenal rat segments ex vivo